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Both semaglutide (brand names Ozempic, Wegovy) and tirzepatide (Mounjaro) are glucagon-like peptide-1 (GLP-1) receptor agonists that work by mimicking a hormone to reduce appetite, however tirzepatide uniquely also activates the glucose-dependent insulinotropic polypeptide (GIP) receptor unlike semaglutide which only activates the GLP-1 receptor

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Whilst GLP-1 receptor activation can exert multiple direct neuroprotective effects, the protective influence of GLP-1 receptor agonists may occur indirectly through the restoration of the dysfunctional insulin signaling associated with neurodegenerative disease

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